Health & Fitness Why is it so hard to quit smoking? Tiny worms may have the answers

08:44  13 november  2017
08:44  13 november  2017 Source:   Journal.ie

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Tiny worms may have the answers . The worms exhibit behavioral responses to nicotine similar to what mammals experience. Recipient's Email. Submit. Feedback on “ Why is it so hard to quit smoking ?

ANN ARBOR–Researchers at the University of Michigan Life Sciences Institute found that a previously dismissed genetic mechanism may contribute to nicotine dependence, and to the withdrawal effects that can make quitting smoking so difficult.

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SCIENTISTS EXAMINING WITHDRAWAL responses in millimeter-long roundworms have found that a previously dismissed genetic mechanism may contribute to nicotine dependence.

Caenorhabditis elegans roundworms get hooked on nicotine just like humans.

Researchers at the University of Michigan Life Sciences Institute identified specific genes and microRNA that play an essential role in how the roundworms develop nicotine dependence and their withdrawal responses.

These clues may carry over to the mammalian realm. Scientists previously demonstrated that the worms exhibit behavioral responses to nicotine similar to what mammals experience, and that some of the genes involved in nicotine dependence in worms are conserved in mammals – meaning the worms are a good genetic and behavioral model for studying nicotine dependence.

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It 's hard to quit smoking because cigarette manufacturers make it hard . Most people know the word, but many may not actually know what it is. Here's the skinny: Nicotine is a naturally occurring colorless liquid in tobacco that turns brown when burned.

Answers .com® WikiAnswers® Categories Health Addictions Smoking and Tobacco Use Smoking Cessation Why is smoking hard to quit ? Then after 50 years of smoking , I have not smoked for 5 years now. But I don't know whether I have totally quit smoking . I may smoke any time again.

The study took a fresh look at a previously dismissed biological mechanism. Most research in the field has focused on how proteins called nicotine acetylcholine receptors contribute to dependence.

Scientists in the lab of Shawn Xu focused on an earlier step in the genetic coding process and discovered that a series of genes were involved in a process that ultimately increased the production of the nicotine receptor proteins, with microRNAs -a class of small RNA molecules that help fine-tune gene expression – playing a pivotal role.

A researcher in Shaun Xu’s lab and one of the lead authors on the study, Jianke Gong said:

We’re seeing a clear link between nicotine, microRNA, the receptor proteins, and nicotine-dependent behavior.

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WikiAnswers® science math history literature technology health law business All Sections. Careers. Answers .com® WikiAnswers® Categories Health Medication and Drugs Illegal Drugs Marijuana Why is it so hard to But I don't know whether I have totally quit smoking . I may smoke any time again.

Related QuestionsMore Answers Below. What's the easiest way to quit smoking ? In no time, one can be free from addiction. Here are a few tips that may help: 1. Make a list of Why is it hard to quit smoking ? How do I easily quit Smoking ? What's the safest non-medical way to quit smoking ?

This mechanism had been dismissed as unimportant to nicotine dependence. However, Xu pointed out, those conclusions were made decades ago, using less sophisticated techniques.

“People believed this question had been settled,” said Xu, a professor at the LSI and in the Department of Molecular and Integrative Physiology at the U-M Medical School.

But we have better tools now. We, as a field, need to take another look at this mechanism in nicotine addiction.

Xu hopes that this latest discovery in C. elegans will now lead other scientists to re-examine the role of these microRNAs in nicotine dependence in mammals, and ultimately lead to a better understanding of what causes the dependence.

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The reason you struggle to get up in the morning might have nothing to do with being tired .
If you've got a closer relationship with the snooze button than your own partner, this could be why.Sure, your bed is nice and warm and cosy and all that, but it shouldn't be this hard to force yourself to get up.

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