Family & Relationships 'Repurposed' drugs can reduce brain shrinkage linked to Alzheimer's disease

13:05  20 april  2017
13:05  20 april  2017 Source:   Press Association

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  How Yoga Could Help Relieve Your Nightmare Back Pain If your life is blighted by back pain, 2017 might just be the year to take up yoga. A new study has found that yoga can help reduce pain and improve movement in those with chronic lower back pain.According to NHS Choices, back pain can be debilitating and distressing. In fact, a 2014 study concluded that, globally, lower back pain caused more disability than any other condition, affecting nearly one in 10 people.Lower back pain is a common health problem and is usually treated with over-the-counter medication. For some people it may last for three months or more, at which point it is considered ‘chronic’.

Two “ repurposed ” drugs have been shown to reduce the kind of brain shrinkage caused by Alzheimer ’ s and other neurodegenerative The drugs blocked an important pathway linked to brain cell death caused by prion disorders such as Creutzfeldt-Jakob disease , and dementia.

' Repurposed ' drugs can reduce brain shrinkage linked to alzheimer ' s disease . The drugs blocked an important pathway linked to brain cell death caused by prion disorders such as Creutzfeldt-Jakob disease , and dementia.

The drugs blocked an important pathway linked to brain cell death caused by prion disorders such as Creutzfeldt-Jakob disease, and dementia: General Stock - Education - May 2008 © PA ARCHIVE IMAGES General Stock - Education - May 2008 Two "repurposed" drugs have been shown to reduce the kind of brain shrinkage caused by Alzheimer's and other neurodegenerative diseases.

Both medicines, one a licensed antidepressant and the other an anti-cancer compound, restored protein production in the brains of laboratory mice.

The drugs blocked an important pathway linked to brain cell death caused by prion disorders such as Creutzfeldt-Jakob disease, and dementia.

Brain damage was prevented in mice with prion disease and animals with frontotemporal dementia (FTD) reclaimed their memory. In both cases, brain shrinkage was reduced.

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Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease . Epidemiologic data linking alzheimer disease and type 2 diabetes.

Swapping faulty genes for healthy ones could 'STOPS Alzheimer ' s in its tracks'. Professor Mohamed Naguib, of the Cleveland Clinic, Ohio, said: “This drug may reduce inflammation in the brain , which is linked to Alzheimer ’ s disease .

The antidepressant trazodone hydrochloride and anti-cancer drug dibenzoylmethane (DBN) were identified after scientists tested 1,040 compounds on laboratory worms and mammalian cells.

Professor Giovanna Mallucci, who led the team from the Medical Research Council's Toxicology Unit in Leicester and Cambridge University, said: "We know that trazodone is safe to use in humans, so a clinical trial is now possible to test whether the protective effects of the drug we see on brain cells in mice with neurodegeneration also applies to people in the early stages of Alzheimer's disease and other dementias.

"We could know in two to three years whether this approach can slow down disease progression, which would be a very exciting first step in treating these disorders.

7 Weird Things Linked to Memory Loss Later in Life

  7 Weird Things Linked to Memory Loss Later in Life 7 Weird Things Linked to Memory Loss Later in LifeScience suggests that what’s good for your body is also good for your mind: Exercise, a balanced diet, and maintaining a healthy weight all seem to be good for the brain, and may even reduce buildup of proteins related to Alzheimer’s disease.

The study was based on the presumption that by controlling the levels of homocysteine, an amino acid, you might be able to reduce the amount of brain shrinkage , which tends to precipitate Alzheimer ' s . High levels of homocysteine are linked to an increased risk of Alzheimer ' s , as well as heart disease

Additional links between obesity and brain shrinkage may be even more fundamental. Protein misfolding and aggregation in Alzheimer ’ s disease and type 2 diabetes mellitus. CNS Neurol Disord Drug Targets. 2014;13(7):1280-93.

"Interestingly, trazodone has been used to treat the symptoms of patients in later stages of dementia, so we know it is safe for this group.

"We now need to find out whether giving the drug to patients at an early stage could help arrest or slow down the disease through its effects on this pathway."

Dr Doug Brown, director of research and development at the Alzheimer's Society, said: "We're excited by the potential of these findings.

"They show that a treatment approach originally discovered in mice with prion disease might also work to prevent the death of brain cells in some forms of dementia.

"This research is at a very early stage and has not yet been tested in people - but as one of the drugs is already available as a treatment for depression, the time taken to get from the lab to the pharmacy could be dramatically reduced.

"The drug blocks a natural defence mechanism in cells which is overactive in the brains of people with frontotemporal dementia, Alzheimer's disease and Parkinson's, so has the potential to work for several conditions."

7 Weird Things Linked to Memory Loss Later in Life

  7 Weird Things Linked to Memory Loss Later in Life 7 Weird Things Linked to Memory Loss Later in LifeScience suggests that what’s good for your body is also good for your mind: Exercise, a balanced diet, and maintaining a healthy weight all seem to be good for the brain, and may even reduce buildup of proteins related to Alzheimer’s disease.

2011-05-03 - Studies implicate new genes in Alzheimer ' s disease .

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The results appear in the journal Brain.

Neuropathologist Dr Payam Rezaie, from the Open University, said: "This is not a cure for neurodegenerative diseases or dementia, it will not reverse the course of illness, and the neuroprotective effects were observed in the majority of, but not in all experimental animals.

"Nevertheless, it could represent a significant step forward in attempting to halt these diseases in their tracks, and as the researchers state, considering its existing licence for use in elderly patients, trazodone in particular would be a potential candidate for clinical trials moving forward."

Related: 20 Foods That Fight Alzheimer's Disease (Provided by Zero Belly)

Fending off Alzheimer's starts with the right foods.: <p>Stay cognitively and physically fit as you age by making these foods a staple in your diet. </p><p>Some say that growing older is a privilege, but for those with a family history of cognitive decline, the prospect of entering your golden years can be a frightening one. More than 5 million Americans are living with Alzheimer’s disease, and as life expectancy continues to rise in developed nations around the world, that number is expected to grow, too. The Alzheimer’s Association suggests that the number of adults living with Alzheimer’s in the United States alone could more than triple by the year 2050. </p><p>While it’s often assumed that Alzheimer’s disease is marked solely by cognitive decline, the disease kills more people than breast cancer and prostate cancer combined, and is the sixth leading cause of death in the United States. Although altering your genetic predisposition to Alzheimer’s and other types of dementia may not be possible, reducing your risk of developing the disease is. </p><p>Research compiled from the Canadian Study of Health and Aging, which studied more than 5,000 senior patients over an 11-year period, reveals that patients who received supplementation with vitamins C and E were significantly less likely to develop Alzheimer’s and other types of dementia than those who didn’t. Fortunately, you don’t have to wait until old age is on the horizon to start making positive changes in your brain; staying active, snacking on the <a href=42 Best Foods For a Healthier Brain, and checking in with your doctor on a regular basis can help keep you healthy well into later life. And if you’re serious about staying cognitively fit as you age, load your menu with vitamins C and E by making the 20 Foods That Fight Alzheimer’s Disease staples in your meal plan starting today!

" src="/upload/images/real/2017/04/20/fending-off-alzheimers-starts-with-the-right-foods-p-stay-cognitively-and-physically-fit-as-you-age-_818592_.jpg" /> 20 Foods That Fight Alzheimer's Disease

Ibuprofen linked to increased risk of cardiac arrest .
One of the most popular over-the-counter painkillers in the UK can heighten the chances of suffering a potentially fatal cardiac arrest, a study has shown. Researchers in Denmark found that taking ibuprofen was associated with a 31% increased risk of the emergency condition, which occurs when the heart suddenly stops pumping blood.Other medicines from the same family of painkillers, known as non-steroidal anti-inflammatory drugs (NSAIDs), posed a similar danger, according to the findings.They included diclofenac, which raised the risk by 50%, and was available over the counter in the UK until 2015.

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